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A Model for the Regulation of Myelopoiesis by Specific Factors
Author(s) -
Bender James G.,
Van Epps Dennis E.,
Stewart Carleton C.
Publication year - 1986
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.39.1.101
Subject(s) - myelopoiesis , biology , haematopoiesis , microbiology and biotechnology , progenitor cell , myeloid , stem cell , cell cycle , lineage (genetic) , immunology , genetics , cell , gene
Hematopoietic cells originate from stem cells that generate progenitor cells programmed to differentiate along specific cell lineages. Recently, a number of factors have been identified that are involved in regulating the proliferation of myeloid lineage cells. We propose a model in which a hierarchy of specific factors acts sequentially during defined stages of maturation to regulate myelopoiesis. The role of these factors as competence or progression factors in causing cells to enter and traverse the cell cycle is discussed. Experimental evidence supports the model.