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Characterization of Human Pericardial Macrophages
Author(s) -
BenhaiemSigaux Nicole,
Mina Elie,
Sigaux François,
Lambré Claude R.,
Valensi Françoise,
Allégret Catherine,
Bernaudin JeanFrançois
Publication year - 1985
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.38.6.709
Subject(s) - biology , pericardial fluid , phagocytosis , population , vimentin , ultrastructure , acid phosphatase , peripheral blood mononuclear cell , microbiology and biotechnology , cell , pericardium , pericardial cavity , pathology , immunology , anatomy , biochemistry , enzyme , medicine , in vitro , immunohistochemistry , demography , sociology
This paper deals with the study of the cell population in 13 samples of normal human pericardial fluid. Large mononuclear cells (LMC) constituted 74.1 ± 18.5% of the total cell population. These LMC possess the characteristics of macrophages: 1) firm adherence to glass, 2) intracytoplasmic presence of vimentin without keratin, 3) ultrastructural observation of a lysosomal apparatus, 4) cytoenzymatic activities: acid phosphatases, naphthol AS.D acetate esterase and peroxidases, and 5) phagocytosis of Baker's yeasts. All these data clearly show that macrophages are the main component of the pericardial fluid cell population and can be of great significance in the defense mechanisms and physiology of the pericardial space.