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Phagocytosis of Unopsonized Zymosan by Human Monocyte‐Derived Macrophages: Maturation and Inhibition by Mannan
Author(s) -
Speert David P.,
Silverstein Samuel C.
Publication year - 1985
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.38.5.655
Subject(s) - zymosan , phagocytosis , opsonin , monocyte , mannan , biology , microbiology and biotechnology , macrophage , in vitro , mannose , antibody opsonization , immunology , biochemistry , polysaccharide
Human monocyte‐derived macrophages phagocytosed zymosan in the absence of serum opsonins. The capacity to ingest zymosan developed after the cells were cultured in vitro for 3 days and was inhibited completely by mannan. We conclude that human monocyte‐derived macrophages phagocytose unopsonized zymosan predominantly via mannose receptors.

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