Enhanced Activity of the Macrophage‐Like Cell Line J774.1 Following Exposure to Gamma Radiation | Zendy

Gallin Elaine K. | Zendy; Green Spencer W. | Zendy; Sheehy Paul A. | Zendy

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Enhanced Activity of the Macrophage‐Like Cell Line J774.1 Following Exposure to Gamma Radiation

Author(s) -

Gallin Elaine K.,

Green Spencer W.,

Sheehy Paul A.

Publication year - 1985

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.38.3.369

Subject(s) - biology , thymidine , cell culture , membrane ruffling , macrophage , staining , cell , microbiology and biotechnology , cobalt 60 , ingestion , endocrinology , andrology , medicine , immunology , biochemistry , in vitro , irradiation , genetics , cytoskeleton , physics , nuclear physics

Exposure of the macrophage‐like cell line J774.1 to 20 gray of cobalt‐60 gamma radiation resulted in a block of tritiated thymidine incorporation, along with an increase in cell “activation,” as assessed by increases in lysosomal enzyme and ectoenzyme content, PMA‐induced H 2 O 2 production, and NBT staining, ingestion of E(IgG), spreading, and membrane ruffling. These changes are evident within 1 day postradiation and peak at 4 days postradiation.

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