Premium
Effect of Prostaglandins on Complement Production by Tissue Macrophages
Author(s) -
Rediske J.J.,
Pickering R.J.
Publication year - 1985
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.37.5.651
Subject(s) - biology , complement (music) , microbiology and biotechnology , production (economics) , complement system , immunology , macrophage , immune system , biochemistry , in vitro , complementation , gene , phenotype , macroeconomics , economics
Tissue macrophages produce several proteins of the complement system. The mechanisms that regulate this process are poorly understood. The established ability of certain prostaglandins to influence macrophage secretory activity suggests that these lipid mediators may also modulate complement production (CP). Using the guinea pig peritoneal macrophages, we determined the effects of selected prostaglandins on in vitro CP and found that 1) PGE 2 inhibited production of complement proteins but not lysozyme; 2) the response of elicited and resident peritoneal cells to PGE 2 was identical; and 3) PGE 1 PGF 2 and PGI 2 had no detectable effect. PGE 2 may contribute to regulation of CP in vivo.