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The Strain of Mouse and Assay Conditions Influence Whether MulFN‐ γ Primes or Activates Macrophages for Tumor Cell Killing
Author(s) -
Pace Judith L.,
Varesio Luigi,
Russell Stephen W.,
Blasi Elisabetta
Publication year - 1985
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.37.4.475
Subject(s) - biology , macrophage , strain (injury) , cytotoxicity , immunology , mouse strain , microbiology and biotechnology , in vitro , biochemistry , gene , anatomy
Investigators from two different laboratories have compared several variables in the short‐term macrophage‐mediated cytotoxicity assays used by each group to study the role of MulFN‐ γin macrophage activation. The findings suggest that the capacity of MulFN‐ γto activate macrophages without the need for a second triggering stimulus is related to assay conditions and, most especially, the strain of mouse used to provide the macrophages.