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The Influence of Parturition on Peripheral Blood Mononuclear Phagocyte Subpopulations in Pregnant Women
Author(s) -
Buchan G.S.,
Gibbins B. L.,
Griffin J.F.T.
Publication year - 1985
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.37.2.231
Subject(s) - percoll , monocytosis , biology , phagocyte , peripheral blood mononuclear cell , peripheral blood , mononuclear phagocyte system , immunology , population , andrology , peripheral , medicine , endocrinology , immune system , centrifugation , in vitro , bone marrow , biochemistry , environmental health
Mononuclear phagocytes (MPs) from human peripheral blood were separated on discontinuous Percoll gradients into two subpopulations. A high density population was isolated which contained less mature MPs, while the MPs in the low density population were more mature cells. The proportion of high density MPs was found to increase sharply in conjunction with the peripheral blood monocytosis associated with parturition in women. The data show that there is a measurable response in the circulating MP pool to this acute inflammatory stimulus and that this response is manifested as an increase in absolute numbers of both total and high density MPs. No significant change was found in the number of low density MPs.