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Inhibition of Yeast Phagocytosis in Macrophage Cultures Treated With Slime Polysaccharide Purified From Pseudomonas aeruginosa
Author(s) -
Grasso Robert J.,
Ganguly Rama,
Breen John F.
Publication year - 1984
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.36.6.771
Subject(s) - phagocytosis , phagocyte , microbiology and biotechnology , biology , macrophage , pseudomonas aeruginosa , virulence , yeast , polysaccharide , virulence factor , in vivo , saccharomyces cerevisiae , in vitro , biochemistry , bacteria , genetics , gene
This study was initiated to determine whether purified slime polysacchar‐ ide(PSP) from P aeruginosa inhibits the ingestion of heat killed Saccharomyces cerevisiae particles in macrophage cultures. Relative to controls, direct phagocytosis assays revealed that the percentages of phagocytes and the numbers of ingested yeast particles per phagocyte decreased in a dose‐dependent manner in PSP‐treated cultures. Thus, PSP may act as a virulence factor in vivo by impairing the phagocytic capacity of macrophages.