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Interferon Fever: Absence of Human Leukocytic Pyrogen Response to Recombinant α‐Interferon
Author(s) -
Ackerman Samuel K.,
Hochstein H. Donald,
Zoon Kathryn,
Browne Walter,
Rivera Evelyn,
Elisberg Bennett
Publication year - 1984
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.36.1.17
Subject(s) - interferon , recombinant dna , biology , immunology , in vitro , pathogenesis , alpha interferon , virology , biochemistry , gene
A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human α‐interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocytic pyrogen. This result suggests that interferon may cause fever by a novel mechanism not dependent on leukocytic pyrogen.