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High Incidence of Langerhans Cells in Lymph Nodes of Athymic Nude Mice: An Ultrastructural and Morphometric Study
Author(s) -
Maruyama T.,
Hasegawa T.,
Kobayashi F.,
Tanaka S.,
Uda H.
Publication year - 1984
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.35.5.441
Subject(s) - lymph , biology , pathology , ultrastructure , medulla , nude mouse , lymph node , anatomy , immunology , medicine , cell culture , genetics
Cervical and axillary lymph nodes of athymic nude mice were compared morphometrically and ultrastructurally with those of normal littermates. The lymph nodes of the nude mice were larger and the volumes of the follicle, paracortex, and medulla of the lymph nodes were all larger. The paracortex of nude mice had few lymphocytes and a large number of interdigitating cells (IDC) and Langerhans cells (Lc). The results suggest that the high incidence of Lc and IDC in the lymph nodes of nude mice is due to cell accumulation and not lymphocyte depletion.