Premium
Macrophage Activation Measured by Changes in 5′‐Nucleotidase and Alkaline Phosphodiesterase I Activities After Infection of Newborn and Juvenile Guinea Pigs With Mycobacterium microti
Author(s) -
Bautista Abraham P.,
Solomon J. Brian
Publication year - 1984
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.35.4.415
Subject(s) - biology , macrophage , juvenile , phosphodiesterase , guinea pig , microbiology and biotechnology , 5' nucleotidase , alkaline phosphatase , immunology , virology , enzyme , biochemistry , endocrinology , ecology , in vitro
Activation of alveolar, peritoneal, liver, and spleen macrophages was measured by decreased 5’‐nucleotidase and elevated alkaline phosphodiesterase I activities in newborn and juvenile guinea pigs for up to 48 days after intracardiac or intranasal infection with Mycobacterium microti. Increased AP and reduced 5’‐nucleotidase activity in cell lysates of macrophages appeared to be related to the carrier state during infection. Intranasal infection of 8‐week‐old guinea pigs with M. microti produced decreases of 5’‐nucleotidase activity in alveolar macrophages during 1–8 weeks post infection and in macrophages from all four sources from 4–8 weeks.