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Decreased Fibronectin Biosynthesis by Human Cord Blood Mononuclear Phagocytes In Vitro
Author(s) -
Gerdes Jeffrey S.,
Douglas Steven D.,
Kolski Gerald B.,
Yoder Mervin C.,
Polin Richard A.
Publication year - 1984
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.35.1.91
Subject(s) - fibronectin , in vitro , monocyte , biology , mononuclear phagocyte system , macrophage , peripheral blood mononuclear cell , cord blood , immunology , biosynthesis , biochemistry , cell , enzyme
Cultured cord blood monocytes synthesize significantly less fibronectin than cultured monocyte‐macrophages from adult peripheral blood. Biosynthesis of the second component of complement in vitro is similar for both cell systems. The monocyte‐macrophages from neonates and adults have similar functional and morphologic properties in long‐term cultures. The decreased monocyte‐macrophage biosynthesis of fibronectin observed in vitro may be in part related to the reduced plasma fibronectin concentrations and reticuloendothelial system hypofunction which occur in newborn infants.