Premium
CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions
Author(s) -
Rozenberg Perri,
Reichman Hadar,
Moshkovits Itay,
Munitz Ariel
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.2mr1117-433r
Subject(s) - biology , eosinophil , receptor , microbiology and biotechnology , chemotaxis , effector , immunology , lineage (genetic) , genetics , gene , asthma
The CD300 family of receptors is an evolutionary conserved receptor family that belongs to the Ig superfamily and is expressed predominantly by the myeloid lineage. Over the past couple of years, accumulating data have shown that eosinophils express various Ig superfamily receptors that regulate key checkpoints in their biology including their maturation, transition from the bone marrow to the peripheral blood, migration, adhesion, survival, and effector functions in response to numerous activating signals such as IL‐4, IL‐33, and bacteria. In this review, we will present the emerging roles of CD300 family receptors and specifically CD300a and CD300f in the regulation of these eosinophil activities. The structure and expression pattern of these molecules will be discussed and their involvement in suppressing or co‐activating eosinophil functions in health and disease will be illustrated.