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Class I myosins: Highly versatile proteins with specific functions in the immune system
Author(s) -
GirónPérez Daniel Alberto,
PiedraQuintero Zayda Lizbeth,
SantosArgumedo Leopoldo
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.1mr0918-350rrr
Subject(s) - biology , microbiology and biotechnology , immunological synapse , exocytosis , cytoskeleton , endocytosis , cytokinesis , myosin , actin cytoskeleton , actin , motor protein , cell , immune system , microtubule , t cell , immunology , cell division , secretion , biochemistry , t cell receptor
Connections established between cytoskeleton and plasma membrane are essential in cellular processes such as cell migration, vesicular trafficking, and cytokinesis. Class I myosins are motor proteins linking the actin‐cytoskeleton with membrane phospholipids. Previous studies have implicated these molecules in cell functions including endocytosis, exocytosis, release of extracellular vesicles and the regulation of cell shape and membrane elasticity. In immune cells, those proteins also are involved in the formation and maintenance of immunological synapse‐related signaling. Thus, these proteins are master regulators of actin cytoskeleton dynamics in different scenarios. Although the localization of class I myosins has been described in vertebrates, their functions, regulation, and mechanical properties are not very well understood. In this review, we focused on and summarized the current understanding of class I myosins in vertebrates with particular emphasis in leukocytes.