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The role of ubiquitinase in B cell development and function
Author(s) -
Zhang Tong,
Sun Jianxuan,
Cheng Jiali,
Yin Wei,
Li Jingwen,
Miller Heather,
Herrada Andrés A.,
Gu Heng,
Song Hongmei,
Chen Yan,
Gong Quan,
Liu Chaohong
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.1mr0720-185rr
Subject(s) - biology , microbiology and biotechnology , signal transduction , haematopoiesis , ubiquitin , function (biology) , b cell , immune system , cell cycle , bone marrow , plasma cell , apoptosis , antibody , stem cell , immunology , genetics , gene
Ubiquitinases are a select group of enzymes that modify target proteins through ubiquitination, which plays a crucial role in the regulation of protein degradation, location, and function. B lymphocytes that originated from bone marrow hematopoietic stem cells (HSC), exert humoral immune functions by differentiating into plasma cells and producing antibodies. Previous studies have shown that ubiquitination is involved in the regulation of the cell cycle and signal transduction important for B lymphocyte development and function. In this review, how ubiquitinases regulate B cell development, activation, apoptosis, and proliferation is discussed, which could help in understanding the physiological processes and diseases related to B cells and also provides potential new targets for further studies.