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Metabolic reprogramming of myeloid‐derived suppressor cells: An innovative approach confronting challenges
Author(s) -
Li Xiaoqing,
Li Yixue,
Yu Qinru,
Qian Pengxu,
Huang He,
Lin Yu
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.1mr0421-597rr
Subject(s) - biology , immune system , myeloid derived suppressor cell , reprogramming , myeloid , microbiology and biotechnology , inflammation , tumor microenvironment , cancer research , immunology , suppressor , cell , cancer , biochemistry , genetics
Immune cells such as T cells, macrophages, dendritic cells, and other immunoregulatory cells undergo metabolic reprogramming in cancer and inflammation‐derived microenvironment to meet specific physiologic and functional demands. Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are characterized by immunosuppressive activity, which plays a key role in host immune homeostasis. In this review, we have discussed the core metabolic pathways, including glycolysis, lipid and fatty acid biosynthesis, and amino acid metabolism in the MDSCs under various pathologic situations. Metabolic reprogramming is a determinant of the phenotype and functions of MDSCs, and is therefore a novel therapeutic possibility in various diseases.