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Gut microbiota shape B cell in health and disease settings
Author(s) -
Yu Baichao,
Wang Luman,
Chu Yiwei
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.1mr0321-660r
Subject(s) - biology , gut flora , immune system , context (archaeology) , immunology , function (biology) , disease , gut–brain axis , microbiome , b cell , microbiology and biotechnology , genetics , antibody , medicine , paleontology , pathology
Recent accumulating evidence supports the hypothesis that the intricate interaction between gut microbiota and the immune system profoundly affects health and disease in humans and mice. In this context, microbiota plays an important role in educating and shaping the host immune system which, in turn, regulates gut microbiota diversity and function to maintain homeostasis. Studies have demonstrated that intestinal microbiota participates in shaping B cells in health and disease settings. Herein, we review the recent progress in understanding how microbiota regulates B‐cell development, focusing on early‐life B‐cell repertoire generation in GALT and how microbial products, including microbial antigens and metabolites, affect B‐cell activation and differentiation to ultimately regulate B‐cell function. We also discuss the interaction between gut microbiota and B cells under pathogenic conditions and highlight new approaches that can be applied to treat various diseases.