Amidine‐Induced Ring Transformation of a Substituted 1,1‐Dioxo‐1,2‐thiazine‐4‐carbaldehyde into New Pyrimidine Derivatives | Zendy

Fanghänel Egon | Zendy; Bartossek Hagen | Zendy; Baumeister Ute | Zendy; Hartung Helmut | Zendy

Premium

Amidine‐Induced Ring Transformation of a Substituted 1,1‐Dioxo‐1,2‐thiazine‐4‐carbaldehyde into New Pyrimidine Derivatives

Author(s) -

Fanghänel Egon,

Bartossek Hagen,

Baumeister Ute,

Hartung Helmut

Publication year - 1997

Publication title -

liebigs annalen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0947-3440

DOI - 10.1002/jlac.199719971230

Subject(s) - amidine , chemistry , thiazine , pyrimidine , ring (chemistry) , transformation (genetics) , hydrolysis , derivative (finance) , medicinal chemistry , stereochemistry , organic chemistry , financial economics , economics , biochemistry , gene

As a masked 1,3‐dicarbonyl compound, the 1,1‐dioxo‐ 2H ‐1,2‐thiazine‐4‐carbaldehyde 1 undergoes ring transformation with amidines to produce 2‐substituted 4‐methyl‐5‐[1‐methyl‐2‐methylthio‐2‐( N ‐phenylsulfamoyl)vinyl]pyrimidines 3a–f . For 3b , an X‐ray structure analysis is reported. From the 4‐methyl‐2‐methylthio‐5‐[1‐methyl‐2‐methylthio‐2‐( N ‐phenylsulfamoyl)vinyl]pyrimidine ( 3e ), the substituted pyrimidinone 4 is obtained by acidic hydrolysis.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research