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Cytotoxic Triterpene Glycosides from Far‐Eastern Sea Cucumbers Belonging to the Genus Cucumaria
Author(s) -
Drozdova Olga A.,
Avilov Sergey A.,
Kalinin Vladimir I.,
Kalinovsky Anatoly I.,
Stonik Valentin A.,
Riguera Ricardo,
Jiménez Carlos
Publication year - 1997
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719971125
Subject(s) - sea cucumber , triterpene , aglycone , glycoside , stereochemistry , chemistry , cytotoxic t cell , genus , biology , botany , in vitro , biochemistry , ecology , medicine , alternative medicine , pathology
New cytotoxic triterpene oligoglycoside disulfates, cucumariosides A 3 ( 1 ) and A 6 ‐2 ( 2 ), have been isolated from the sea cucumber Cucumaria japonica . The trisulfated cucumarioside A 7 ‐3 ( 4 ) was found to be the major component in the glycoside fraction of Cucumaria miniata . The structures were assigned on the basis of extensive spectral data (NMR and MS), selective solvolysis of desulfated derivative 3 and other chemical evidence. The presence or absence of a carbonyl group at C‐16 of the aglycone and of sulfate groups at C‐6 of the glucose and 3‐ O ‐methylglucose units are interpreted in terms of the functional evolution of sea cucumbers in order to improve their defensive system. Both ( 1 ) and ( 2 ) are cytotoxic in vitro at IC 50 = 1 μg/ml against a selection of five human and mice tumoral cell lines.

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