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Synthesis of Novel C 2 ‐Symmetrical Diamino Thioethers Derived from Amino Acids
Author(s) -
Christoffers Jens
Publication year - 1997
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719970711
Subject(s) - thioether , chemistry , amino acid , amide , stereochemistry , transition metal , sequence (biology) , metal , combinatorial chemistry , organic chemistry , catalysis , biochemistry
Chiral β‐amino alcohols 2 , available from natural α‐amino acids by reduction, have been converted in a sequence of N ‐protection, O ‐activation, thioether formation, and deprotection to novel C 2 ‐symmetrical β,β′‐diamino thioethers 1 , which shall serve as chiral tridentate ligands in late transition metal complexes. Optical purity of compounds 1 was established by amide formation with (+)‐ O ‐acetylmandelic acid.