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Reaction of α‐Hydroxyamino Ketones with Dicarbonyl Compounds – Synthesis of Imidazoline Nitroxides with a Functional Group in a Side Chain
Author(s) -
Reznikov Vladimir A.,
Volodarsky Leonid B.
Publication year - 1997
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719970537
Subject(s) - chemistry , imidazoline receptor , acetone , side chain , ammonium acetate , functional group , carbonyl group , ketone , ammonium , diacetyl , medicinal chemistry , organic chemistry , medicine , high performance liquid chromatography , polymer
The reaction of α‐hydroxyamino ketones 1 with diacetyl, acetyl acetone or acetoacetic ester in the presence of ammonium acetate results in the formation of 3‐imidazoline derivatives 2 , which are precursors for the synthesis of stable nitroxides 8, 9, 14, 16, 17, 23–24 with various functional groups in the side chain at the 2‐position of the heterocycle.