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Bis(guanidinium) Receptors as Ribonuclease Active‐Site Model Systems: Structural Changes and Solvent Effects
Author(s) -
Oost Thorsten,
Filippazzi Anna,
Kalesse Markus
Publication year - 1997
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719970532
Subject(s) - chemistry , acetonitrile , ribonuclease , guanidinium chloride , cleave , solvent , stereochemistry , polymer chemistry , combinatorial chemistry , rna , organic chemistry , enzyme , biochemistry , gene
Abstract Various bis(guanidinium) compounds have been synthesized and their abilities to cleave the RNA model compound HPNPP have been tested in acetonitrile and in water. Depending on the spacer length, the substitution of the guanidinium groups, and the presence of an internal base, different rate constants for the transesterification of HPNPP are observed in these two media. The steroid derived bis(guanidinium) compound 12 was identified as a superior system.