Chemistry of Ginkgolides, VII . Preparation and Crystal Structure Analysis of a Secondary Ozonide from Ginkgolide A | Zendy

Weinges Klaus | Zendy; Schick Hartmut | Zendy; Pritzkow Hans | Zendy

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Chemistry of Ginkgolides, VII . Preparation and Crystal Structure Analysis of a Secondary Ozonide from Ginkgolide A

Author(s) -

Weinges Klaus,

Schick Hartmut,

Pritzkow Hans

Publication year - 1997

Publication title -

liebigs annalen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0947-3440

DOI - 10.1002/jlac.199719970529

Subject(s) - ozonide , chemistry , ozonolysis , diazomethane , ginkgolides , derivative (finance) , organic chemistry , medicinal chemistry , stereochemistry , ginkgo , botany , financial economics , economics , biology

By hydrogenation of 3,14‐didehydro‐10‐hydroxyginkgolide (3,14‐anhydroginkgolide A, 1 ) the 3,14‐didehydro‐10‐hydroxyginkgolide‐15‐acid ( 2 ) was obtained. Reaction with diazomethane led to the methyl ester 2a , which was transformed into its MOM derivative 2b . Ozonolysis of 2b gave a stable secondary ozonide 3 and 10‐methoxymethoxy‐3‐oxo‐14,15,16‐trinorginkgolide ( 4 ).

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