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Synthetic Microbial Chemistry, XXX . Synthesis of Acetophthalidin, a Fungal Metabolite which Inhibits the Progression of the Mammalian Cell Cycle
Author(s) -
Nomoto Shin,
Mori Kenji
Publication year - 1997
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719970412
Subject(s) - chemistry , metabolite , hydrolysis , biochemistry , secondary metabolite , cell , cell cycle progression , organic chemistry , cell cycle , gene
Acetophthalidin [(±)‐3‐acetyl‐5,7‐dihydroxyphthalide ( 1 )] was synthesized from 6,8‐diacetoxy‐3‐methylisocoumarin ( 8 ) by its epoxidation followed by hydrolysis.