Premium
A Tandem Claisen‐Decarboxylation‐Aldol Reaction – Facile Access to The Fredericamycin A Core
Author(s) -
Baskaran Sundarababu,
Nagy Edgar,
Braun Manfred
Publication year - 1997
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719970206
Subject(s) - chemistry , decarboxylation , aldol reaction , tandem , diastereomer , deprotonation , core (optical fiber) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , ion , materials science , composite material
A tandem reaction of doubly deprotonated indanecarboxylic acid 3 with ethoxyphthalide 5 leads to the formation of the spirocyclic diastereomers 6a and the 6b in a ratio of 9:1. They are converted to the spirodiketone core 2 of fredericamycin A (1).