Premium
Secondary Fungal Metabolites and Their Biological Activity, VIII . – Partial Synthesis of Oosponol, an Antifungal Isocoumarin
Author(s) -
Kovács Tibor,
Sonnenbichler Johann
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199719970130
Subject(s) - isocoumarin , chemistry , acetylation , antifungal , regioselectivity , lipase , enzyme , organic chemistry , hydrolysis , isocoumarins , biochemistry , catalysis , combinatorial chemistry , microbiology and biotechnology , biology , gene
The partial synthesis of oosponol ( 4 ), which shows significant antibiotic activity, has been accomplished by enzyme catalyzed reactions including regioselective acetylation of (−)‐oospoglycol ( 1 ) followed by an oxidation step and hydrolysis by a lipase.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom