Premium
2‐Chloro‐4,5‐dihydroimidazole, 8 . Syntheses of Novel Fused Heterocyclic Systems by Reactions of 1,2‐Dihydro‐2‐(4,5‐dihydroimidazol‐2‐yl)phthalazin‐1‐ol with Active Methylene Compounds
Author(s) -
Saczewski Franciszek,
Gdaniec Maria
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619961028
Subject(s) - phthalazine , chemistry , pyridazine , methylene , aqueous solution , organic chemistry , medicinal chemistry , combinatorial chemistry
Three‐component reactions of 1 with pyridazine or phthalazine afforded the 1,2‐dihydro derivatives 2a and 2b , respectively. A similar reaction of 1 with phthalazine performed in aqueous NaOH led to the formation of pseudobase 3 . The latter compound proved to be an excellent substrate for the preparation of a series of novel 1,2‐dihydrophthalazine derivatives 4a–c, 5 as well as 6a–b by reactions with a variety of active methylene compounds.