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Synthetic Microbiol Chemistry, XXIX! . Synthesis of Both the Enantiomers of Incrustoporin, an Antibiotic from Incrustoporia carneola
Author(s) -
Yajima Arata,
Mori Kenji
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960707
Subject(s) - chemistry , enantiomer , stereochemistry , combinatorial chemistry , antibiotics , biochemistry
Both the enantiomers of incrustoporin (2‐ p ‐tolyl‐2‐hexen‐4‐olide, 1 ) were synthesized by starting from methyl p ‐tolylacetate ( 2 ) and ( S )‐1,2‐epoxybutane ( 3 ). The naturally occurring compound 1 was shown to possess the R configuration.