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Unexpected Pyrazole → 1,2,4‐Triazole Ring Transformation
Author(s) -
Moderhack Dietrich
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960522
Subject(s) - chemistry , pyrazole , ketone , ring (chemistry) , transformation (genetics) , triazole , combinatorial chemistry , 1,2,4 triazole , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , gene
The pyrazolyl‐substituted amidrazones 3 were found to undergo slow conversion into the 1,2,4‐triazolyl ketone hydrazones 8 when kept in ethanolic solution at 20°C. The crucial step in this transformation is apparently air oxidation of 3 to the intermediate 4 , since employment of an additional oxidant greatly enhanced the rate.