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Facile Synthesis of Polycyclic pyridines, Bipyridines, and Oligopyridines
Author(s) -
Keuper Ralf,
Risch Nikolaus
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960512
Subject(s) - chemistry , domino , yield (engineering) , ketone , mannich reaction , cascade reaction , organic chemistry , nitrogen , combinatorial chemistry , catalysis , materials science , metallurgy
The preparation of polycyclic heterocycles with one or more nitrogen atoms and different binding angles by a domino reaction is described. These compounds ( 4 – 6 , 8a – b ) are formed by the reaction of β‐amino ketone hydrochlorides 1 or 2 (Mannich bases) with ketones 3 . Especially the synthesis of the terpyridines 8a and 8b in a double domino reaction is very useful (yield 70 and 59%) and opens a route to torands.
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