Premium
Ring Closure of 4‐Azido‐3‐formyl‐(or Acetyl‐)2‐pyridones to Isoxazolo[4,3‐ c ]pyridones
Author(s) -
Khattab Ahmed F.
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960314
Subject(s) - chemistry , aldehyde , quinoline , ring (chemistry) , amination , derivative (finance) , closure (psychology) , medicinal chemistry , reductive amination , thermal decomposition , stereochemistry , organic chemistry , catalysis , market economy , financial economics , economics
Azidation of the chlor aldehyde 2 , which was obtained from the 4‐hydroxy‐2‐pyridone 1 , afforded the ring‐closed isoxazolopyridone 3 . Thermolysis of the 3‐acetyl‐4‐azido‐2‐pyridone 8 , which was obtained from the corresponding 4‐tosyloxy derivative 7 , afforded isoxazolopyridine 9 . Amination of the chloro aldehyde 2 yielded the pyrido[4,3‐ b ]quinoline 11 instead of the 4‐chloroazomethine 10 .