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Antibiotics from Gliding Bacteria, LXX Chondramides A–D, New Cytostatic and Antifungal Cyclodepsipeptides from Chondromyces crocatus (Myxobacteria): Isolation and Structure Elucidation
Author(s) -
Jansen Rolf,
Kunze Brigitte,
Reichenbach Hans,
Höfle Gerhard
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960220
Subject(s) - myxobacteria , depsipeptide , antifungal , polyketide , chemistry , antibiotics , stereochemistry , microbiology and biotechnology , isolation (microbiology) , bacteria , biochemistry , biology , biosynthesis , genetics , gene
Abstract As a result of the extension of our screening to strains of Chondromyces four new antifungal and highly cytostatic depsipeptides were isolated, the chondramides A ( 1 ) – D ( 4 ). Their macrocyclic structures comprise three amino acids and a polyketide, viz. alanine, N ‐methyltryptophan, α‐methoxyl‐β‐tyrosine, and a 7 ‐hydroxytrimethyloctenoic acid. Thus, they were found to be closely related to a small class of cyclodepsipeptides including jaspamide, the geodiamolides, and neosiphoniamolide which all have been isolated from marine sponges.