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A Concise and Stereoselective Synthesis of threo ‐γ‐Hydroxy‐ l ‐β‐lysine Lactone
Author(s) -
Misiti Domenico,
Zappia Giovanni,
Monache Giuliano Delle
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960213
Subject(s) - stereoselectivity , chemistry , lysine , phenylalanine , lactone , stereochemistry , allylamine , amino acid , alcohol , aspartic acid , organic chemistry , biochemistry , catalysis , polymer , polyelectrolyte
A stereoselective synthesis of threo ‐γ‐hydroxy‐β‐ l ‐lysine lactone is reported. The threo ‐amino alcohol functionality is introduced by iodine‐mediated cyclocarbamation of the electron poor allylamine 6 . The D ‐phenylalanine was used as starting material as synthetic equivalent to D ‐aspartic acid.
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