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Efficient Synthesis of 1,4‐Thiazepin‐3‐one Derivatives and Their Ring Transformations
Author(s) -
Zaleska Barbara,
Cież Dariusz,
Grochowski Jacek,
Serda Pawel,
Winnik Witold
Publication year - 1996
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199619960210
Subject(s) - chemistry , ring (chemistry) , halide , transformation (genetics) , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , gene
A new one‐pot synthesis of title compounds 2 by reaction of β‐aminothiocinnamic acid anilides 1 with α‐haloacid halides is described. The ring of 1,4‐thiazepine 2 in basic medium undergoes transformation to thiazolidin‐4‐ones 5 .
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