On the chemistry of α‐formyl‐2‐hydroxyacetophenone | Zendy

Széll T. | Zendy; Sohár P. | Zendy; Horváth Gy. | Zendy

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On the chemistry of α‐formyl‐2‐hydroxyacetophenone

Author(s) -

Széll T.,

Sohár P.,

Horváth Gy.

Publication year - 1995

Publication title -

liebigs annalen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0947-3440

DOI - 10.1002/jlac.1995199511286

Subject(s) - chemistry , benzaldehyde , chromone , piperidine , condensation , boiling , organic chemistry , ethanol , medicinal chemistry , catalysis , physics , thermodynamics

The title compound 1 undergoes cyclization and self‐condensation in the presence of dil. NaOH yielding chromone ( 2 ) and/or 1‐(3‐chromonyl)‐2‐(2‐hydroxybenzoyl)ethene ( 3 ). With benzaldehyde in the presence of piperidine in boiling ethanol, 1 reacts both by cyclization, and self‐condensation combined with cyclization to give 2, 3 and bis(3‐chromonyl‐phenyl)methane ( 5 ). If less than 0.1 M aq. NaOH is used 1 and benzaldehyde produces 3‐(α‐hydroxybenzoyl)chromone ( 4 ) which can also be converted into 5 .

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