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Resolution of racemic 1‐azaadamantane derivatives by pig liver esterase catalysis
Author(s) -
Mölm Detlef,
Risch Nikolaus
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.1995199510267
Subject(s) - chemistry , kinetic resolution , enantiomer , esterase , pig liver , aqueous solution , resolution (logic) , catalysis , organic chemistry , stereochemistry , enantioselective synthesis , enzyme , artificial intelligence , computer science
The first kinetic resolution of racemic 1‐azaadamantane derivatives with PLE led to the enantiomers (−)‐ 1 and (−)‐ 2 . An unexpected formation of 3 from 1 in aqueous solution was observed.