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Cyclodehydrogenation of 2′‐hydroxychalcones with hypervalent iodine reagent: A new synthesis of flavones
Author(s) -
Litkei György,
Gulácsi Katalin,
Antus Sandor,
Blaskó Gábor
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.1995199509240
Subject(s) - chemistry , hypervalent molecule , flavones , iodine , chrysin , potassium hydroxide , reagent , methanol , organic chemistry , luteolin , flavonoid , chromatography , antioxidant
A new synthesis of chrysin ( 1 ) and luteolin ( 4 ) was accomplished by the cyclodehydrogenation of the appropriately substituted 2′‐hydroxychalcones 21 and 22 in the presence of iodosobenzene diacetate/potassium hydroxide in methanol. The scope and limitation of this transformation is discussed.