Premium
Cyclodehydrogenation of 2′‐hydroxychalcones with hypervalent iodine reagent: A new synthesis of flavones
Author(s) -
Litkei György,
Gulácsi Katalin,
Antus Sandor,
Blaskó Gábor
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.1995199509240
Subject(s) - chemistry , hypervalent molecule , flavones , iodine , chrysin , potassium hydroxide , reagent , methanol , organic chemistry , luteolin , flavonoid , chromatography , antioxidant
A new synthesis of chrysin ( 1 ) and luteolin ( 4 ) was accomplished by the cyclodehydrogenation of the appropriately substituted 2′‐hydroxychalcones 21 and 22 in the presence of iodosobenzene diacetate/potassium hydroxide in methanol. The scope and limitation of this transformation is discussed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom