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Syntheses of putative metabolites of 1,2,3,4‐tetrahydro‐7,12‐dimethylbenz[ a ]anthracene
Author(s) -
Srivastava Santosh K.,
Sharma Pradeep K.
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.1995199509223
Subject(s) - anthracene , 7,12 dimethylbenz[a]anthracene , chemistry , diol , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , dmba , carcinogenesis , gene
Syntheses of (8α,9α,10α,11β)‐ trans ‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol ( 3 ) and (8α,9α,10β,11α)‐ trans ‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol ( 4 ), the putative D‐ring metabolites of 1,2,3,4‐tetrahydro‐7,12‐dimethyl‐benz[a]anthracene ( 1 ), starting from 1,2,3,4‐tetrahydro‐10‐methoxy‐7,12‐dimethylbenz[ a ]anthracene ( 11 ), are reported.