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Stereoselective synthesis of oligo(tetrahydrofurans): Linear and convergent routes to bi‐ and tertetrahydrofurans
Author(s) -
Koert Ulrich,
Stein Matthias,
Wagner Holger
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.1995199508192
Subject(s) - chemistry , stereoselectivity , annonaceae , stereochemistry , convergent synthesis , combinatorial chemistry , organic chemistry , botany , biology , catalysis
The „dimeric” and „trimeric” oligo(tetrahydrofurans) (oligo‐THFs) 24, 28, 32 , and 38 were synthesized stereoselectively according to a linear and a convergent synthetic strategy. The oligo‐THFs thus obtained are important intermediates for the synthesis of artificial ion channels. Furthermore, they can be used in the total synthesis of Annonaceae acetogenins, a class of natural occurring oligo‐THFs with promising pharmacological properties.