Premium
Metabolic products of microorganisms, 271. Momofulvenone A and B, new benzo[ b ]fluorene quinones from Streptomyces
Author(s) -
Volkmann Corinna,
Rössner Ellen,
Metzler Monika,
Zähner Hans,
Zeeck Axel
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.1995199507158
Subject(s) - fluorene , chemistry , polyketide , streptomyces , stereochemistry , fermentation , strain (injury) , ammonium acetate , microorganism , salt (chemistry) , organic chemistry , bacteria , biosynthesis , enzyme , polymer , biology , high performance liquid chromatography , anatomy , genetics
From the cultures of Streptomyces diastatochromogenes (strain Tü 2895) two novel benzo[ b ]fluorene quinones, named momofulvenone A ( 1 ) and B ( 2 ), were isolated. Difficulties in their spectroscopic characterization due to salt effects were overcome by fermentation in the presence of ammonium acetate. The structures were established by a detailed spectroscopic analysis. The polyketide origin of 1 and 2 was verified by feeding [1,2‐ 13 C 2 ]acetate to the growing cultures of Tü 2895. The momofulvenones represent the nitrogen‐free parent compound of the kinamycin family of antibiotics.