Antibiotics from Gliding Bacteria, LXIII. Ratjadone: A New Antifungal Metabolite from  Sorangium cellulosum | Zendy

Schummer Dietmar | Zendy; Gerth Klaus | Zendy; Reichenbach Hans | Zendy; Höfle Gerhard | Zendy

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Antibiotics from Gliding Bacteria, LXIII. Ratjadone: A New Antifungal Metabolite from Sorangium cellulosum

Author(s) -

Schummer Dietmar,

Gerth Klaus,

Reichenbach Hans,

Höfle Gerhard

Publication year - 1995

Publication title -

liebigs annalen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0947-3440

DOI - 10.1002/jlac.199519950497

Subject(s) - polyketide , chemistry , metabolite , antifungal , secondary metabolite , bacteria , antibiotics , stereochemistry , dihydropyran , fermentation , chromatography , strain (injury) , microbiology and biotechnology , biochemistry , biosynthesis , biology , catalysis , genetics , anatomy , gene , enzyme

The antifungal metabolite ratjadone ( 1 ) was isolated from the myxobacterium Sorangium cellulosum , strain So ce360. Production was achieved by fermentation in the presence of the adsorber resin XAD‐16, extraction and separation by RP chromatography. The structure of 1 was determined by spectroscopic methods. It is characterized by a 4‐hydroxytetrahydropyran and a 5,6‐dihydropyran‐2‐one ring which are connected by an unsaturated C 11 carbon chain. The polyketide origin of 1 was proven by feeding experiments with 13 C‐labeled precursors and NMR spectroscopic examinations.

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