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Synthesis of substituted chiral piperazinones as building blocks for peptidomimetics
Author(s) -
Kolter Thomas,
Dahl Christina,
Giannis Athanassios
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199519950487
Subject(s) - peptidomimetic , chemistry , d glucosamine , glucosamine , hydrochloride , combinatorial chemistry , amino acid , stereochemistry , organic chemistry , peptide , biochemistry
Abstract A new approach to 3,6‐disubstituted chiral piperazinones 6a, b and 7a, b from D‐glucosamine hydrochloride ( 1 ) or N ‐Z‐ D ‐glucosamine ( 8 ) and L‐amino acid derivatives 2a, b or 9a, b is presented. Both final products and the intermediate pseudopeptides constitute valuable starting materials for the synthesis of peptidomimetics.