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Neue Synthese von 4‐Azaphenothiazin
Author(s) -
Kutscher Bernhard,
Dieter Hans Reinhold,
Trömer HansGünther,
Bartz Beate,
Engel Jürgen,
Kleemann Axel
Publication year - 1995
Publication title -
liebigs annalen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0947-3440
DOI - 10.1002/jlac.199519950381
Subject(s) - chemistry , stereochemistry , medicinal chemistry , combinatorial chemistry
New Synthesis of 4‐Azaphenothiazine Herrn Dr. W. A. Schuler zum 80. Geburtstag gewidmet. The reaction of 2‐chloropyridine with 2‐aminothiophenol gives N ‐(2‐mercaptophenyl)‐2‐pyridinamine (2) which is cyclised to give 4‐azaphenothiazine (3) , a useful intermediate for pharmaceuticals. An improved one‐pot synthesis is reported and a reaction mechanism proposed.