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Zur Dimerisierung von Indolizinen an Palladium‐Kohle
Author(s) -
Kreher Thomas,
Sonnenschein Helmut,
Schmidt Lothar,
Hünig Siegfried
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419941206
Subject(s) - chemistry
Dimerisation of Indolizines by Palladium Coal Oxidative dimerisation of some indolizines by Pd/C in p ‐xylene was undertaken in order to evaluate reaction conditions for cyclophane syntheses. Surprisingly, alkylation by the solvent occurred at the 3‐position of the indolizines 2 and 5 as a side reaction. In toluene, yields of alkylation products 4b and 8 exceeded those of dimerisation products 3 and 6 . The alkylation by the solvent was fully suppressed by using chlorobenzene or chlorotoluene. Alkylation products of indolizines with p ‐xylene or toluene and previously unknown dimeric indolizines are described.