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Synthesis of (2 R ,5 R )‐5‐Chloropipecolic Acid via a Homochiral Acyliminium Ion Intermediate
Author(s) -
Herdeis Claus,
Held Walter A.,
Kirfel Armin
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419941111
Subject(s) - chemistry , carboxylate , hydrochloride , stereochemistry , ion , medicinal chemistry , combinatorial chemistry , organic chemistry
An efficient synthesis of (2 R ,5 R )‐5‐chloropipecolic acid hydrochloride ( 11 ) is described, starting from the readily available methyl ( S )‐5‐( tert ‐butyldimethylsilyloxy)‐2‐oxopiperidine‐1‐carboxylate ( 3 ).