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Biologically Active Metabolites from Fungi, 5. Palmarumycins C 1 –C 16 from Coniothyrium sp.: Isolation, Structure Elucidation, and Biological Activity
Author(s) -
Krohn Karsten,
Michel Andreas,
Flörke Ulrich,
Aust HansJürgen,
Draeger Siegfried,
Schulz Barbara
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419941108
Subject(s) - chemistry , antifungal , stereochemistry , biological activity , isolation (microbiology) , acetal , antibacterial activity , bacteria , microbiology and biotechnology , biochemistry , biology , in vitro , genetics
Twelve new spiro acetal metabolites, the palmarumycins C 1 –C 8 , ( 1–8 ), C 11 ( 11 ), C 12 ( 12 ), C 15 ( 15 ), C 16 ( 16 ), and three known representatives ( 10, 13, 14 ) of this new class of antibiotics were isolated from Coniothyrium sp. The compounds show antibacterial, antifungal and herbicidal activity at concentrations of 10 −6 –10 −4 mol/l. The structures of palmarumycin C 2 ( 2 ), palmarumycin C 3 ( 3 ), and palmarumycin C 5 ( 5 ) were confirmed by X‐ray structure analysis.