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Biologically Active Metabolites from Fungi, 4. Palmarumycins CP 1 –CP 4 from Coniothyrium palmarum : Isolation, Structure Elucidation, and Biological Activity
Author(s) -
Krohn Karsten,
Michel Andreas,
Flörke Ulrich,
Aust HansJürgen,
Draeger Siegfried,
Schulz Barbara
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419941107
Subject(s) - chemistry , antifungal , stereochemistry , biological activity , isolation (microbiology) , naphthalene , antibiotics , antibacterial activity , biochemistry , bacteria , microbiology and biotechnology , organic chemistry , biology , in vitro , genetics
Four new penta‐ and hexacyclic antifungal and antibacterial metabolites, the palmarumycins CP 1 –CP 4 ( 1–4 ), were isolated from Coniothyrium palmarum . In these structurally unique antibiotics, a 1,8‐dihydroxynaphthalene unit is connected by a spiroacetal to another partially reduced naphthalene unit. The structure of the pentacyclic palmarumycin CP 3 ( 3 ) was confirmed by X‐ray structure analysis.