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Chemie von Aziridincarbonsäuren, IV. Enantioselektive Hydratisierung von Aziridin‐2‐carbonitril
Author(s) -
Jähnisch Klaus,
Gründemann Egon,
Kunath Annamarie,
Ramm Matthias
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940906
Subject(s) - aziridine , chemistry , enantioselective synthesis , aqueous solution , catalysis , aqueous medium , organic chemistry , medicinal chemistry , ring (chemistry)
Chemistry of Aziridinecarboxylic Acids, IV. – Enantioselective Hydration of Aziridine‐2‐carbonitrile Aziridine‐2‐carbonitrile rac ‐ 1 was hydrated enantioselectively in aqueous medium by using (2 R ,3 R ,5 R )‐(−)‐5‐(1‐hydroxy‐1‐methylethyl)‐2‐methyl‐3‐oxocyclohexanecarbonitrile (2) as chiral catalyst. The ee value of the unreacted (S)‐(−)‐aziridine‐2‐carbonitrile 1 depends on the conversion and reaches ≥99%.