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The Absolute Configuration of Muamvatin
Author(s) -
Dahmann Georg,
Hoffmann Reinhard W.
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940813
Subject(s) - absolute configuration , chemistry , absolute (philosophy) , stereochemistry , epistemology , philosophy
A degradation product 2 of muamvatin has been synthesized starting from the stereodefined building blocks 7 and 9 . This synthesis allowed assignment of the absolute configuration of muamvatin as well as of the relative configuration at all stereocenters except for C‐11. The latter configuration is proposed on the basis of the 1 H‐NMR data of natural muamvatin. Attempts have been made to clarify the configuration at C‐11 of muamvatin by synthesis starting from the aldehyde 9 and the ketones 28 .