Thioalkylation of Enolates, III. Stereoselective Synthesis of Steroids and Related Compounds, II α‐Thioalkylation of Zinc Dienolates to 4‐Substituted 1‐ tert ‐Butoxy‐7a‐methyl‐hexahydroinden‐5‐ones | Zendy

Groth Ulrich | Zendy; Köhler Thomas | Zendy; Taapken Thomas | Zendy

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Thioalkylation of Enolates, III. Stereoselective Synthesis of Steroids and Related Compounds, II α‐Thioalkylation of Zinc Dienolates to 4‐Substituted 1‐ tert ‐Butoxy‐7a‐methyl‐hexahydroinden‐5‐ones

Author(s) -

Groth Ulrich,

Köhler Thomas,

Taapken Thomas

Publication year - 1994

Publication title -

liebigs annalen der chemie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0170-2041

DOI - 10.1002/jlac.199419940705

Subject(s) - chemistry , zinc , alkylation , ketone , stereoselectivity , flue gas desulfurization , methyl ketone , organic chemistry , medicinal chemistry , stereochemistry , catalysis

α‐Alkylation of the α,β‐unsaturated ketone 1 at C‐4 has been achieved by thioalkylation of the corresponding zinc dienolate with α‐chlorosulfides of type 2 . The desulfurization of the β‐(phenylthio) ketones 4 leads directly to the 4‐substituted hexahydroinden‐5‐ones 5 .

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